When it comes to brain health, most people think of omega-3s, B vitamins, or nootropics—but one of the most powerful neuroprotective compounds is something your own gut naturally produces: butyric acid.

NuBrain™ includes this often-overlooked molecule for a very specific reason—its profound ability to bridge the gut-brain connection, enhance neurological resilience, and reduce inflammation from the inside out. Let’s take a closer look at what butyric acid is, how it works, and why it plays a starring role in this advanced cognitive support formula.

What Is Butyric Acid?

Butyric acid (also known as butanoic acid) is a short-chain fatty acid (SCFA) produced by beneficial gut bacteria during the fermentation of dietary fiber. It’s one of the primary fuels for colonocytes (cells in the colon) and plays a crucial role in maintaining gut integrity, immune balance, and anti-inflammatory signaling throughout the body.

While naturally occurring in the gut, butyric acid is also available in supplemental form to deliver more targeted and therapeutic effects—especially when combined with other synergistic ingredients.

Butyric Acid and the Gut-Brain Axis

Emerging research shows that butyric acid has direct neurological effects, primarily by modulating the gut-brain axis—the bidirectional communication system between your gut microbiome and your central nervous system.

Here’s how butyric acid supports brain function:

• Reduces neuroinflammation by inhibiting inflammatory cytokines

• Supports the blood-brain barrier integrity

• Enhances BDNF (brain-derived neurotrophic factor) levels

• Improves mitochondrial function and energy production in the brain

• Modulates mood and cognition via neurotransmitter pathways

These effects make butyric acid especially relevant for concerns like brain fog, fatigue, low mood, cognitive decline, and even metabolic dysfunction.

Why Butyric Acid Is in NuBrain™

NuBrain™ by PEAK is a clinically formulated cognitive support product designed to provide dual-action neurological and metabolic support. At its core is the patented BHB-BA™ technology—a unique pairing of exogenous ketones (BHB) and butyric acid for targeted brain fuel and inflammation modulation.

This synergy provides:

• Rapid cognitive energy via ketones

• Sustained anti-inflammatory and gut-brain benefits via butyric acid

• Enhanced BDNF production, supporting neuroplasticity and brain repair

• Mood and focus support, without caffeine or stimulants

Unlike typical brain supplements that only address neurotransmitters or blood flow, NuBrain™ targets the underlying mechanisms of cognitive decline—oxidative stress, inflammation, and impaired mitochondrial energy—using cutting-edge ingredients.

The Clinical Advantage

Butyric acid’s inclusion in NuBrain™ is based on its growing recognition in functional neurology and gut-brain medicine. When paired with exogenous ketones, it provides:

• A dual fuel source for neurons

• Insulin-independent energy

• Anti-inflammatory signaling across the gut and brain

• Support for both short-term performance and long-term brain health

It’s not just about boosting focus for a few hours—it’s about restoring the foundation of healthy brain function.

Final Thoughts

Butyric acid may not be the most well-known brain nutrient, but its research-backed ability to reduce inflammation, enhance energy metabolism, and optimize the gut-brain axis makes it a cornerstone in modern cognitive health strategies.

In NuBrain™, this clinically validated compound is precisely dosed and paired with synergistic ingredients for real-world results that practitioners and patients can feel.

Discover the power of butyric acid + ketones.
Explore PEAK’s NuBrain™—advanced brain fuel backed by science, trusted by professionals.